Madonna ha trabajado para los siguientes directores: Steve Barron, Mary Lambert, Harold Becker, Susan Seidelman, James Foley, Jean-Baptiste Mondino, David Fincher, Herb Ritts, Warren Beatty, Woody Allen, Penny Marshall, Mark Romanek, Abel Ferrara, Paul Auster, Wayne Wang, Allison Anders, Spike Lee, Alan Parker, Chris Cunningham, Jonas Akerlund, Brett Ratner, John Schlesinger, Guy Ritchie, Lee Tamahori, Luc Besson,
En sus películas ha trabajado junto a los siguientes actores: Matthew Modine, Linda Fiorentino, Rosanna Arquette, Aidan Quinn, Robert Joy, Laurie Metcalf, Will Patton, John Turturro, Giancarlo Esposito, Sean Penn, Griffin Dunne, Haviland Morris, John Mills, Stanley Tucci, Matt Dillon, Jennifer Grey, Rutger Hauer, Randy Quaid, Julie Hagerty, Esai Morales, Josef Sommer, Fisher Stevens, Michael Wincott, Steve Buscemi, Warren Beatty, Al Pacino, Mandy Patinkin, Glenne Headly, Charlie Korsmo, William Forsythe, Ed O´Ross, Paul Sorvino, Dustin Hoffman, James Caan, Seymour Cassel, Estelle Parsons, James Keane, Charles Durning, Kathy Bates, Colm Meaney, Catherine O´Hara, Woody Allen, Mia Farrow, John Cusack, Jodie Foster, John Malkovich, Donald Pleasence, Kate Nelligan, Lily Tomlin, Fred Gwynne, Julie Kavner, Kenneth Mars, Wallace Shawn, David Ogden Stiers, Philip Bosco, Kurtwood Smith, James Rebhorn, Victor Argo, Daniel Von Bargen, John C. Reilly, William H. Macy, Tom Hanks, Geena Davis, Lori Petty, Rosie O´Donnell, Jon Lovitz, David Strathairn, Bill Pullman, Garry Marshall, Megan Cavanagh, Willem Dafoe, Joe Mantegna, Anne Archer, Jurgen Prochnow, Julianne Moore, Frank Langella, Stan Shaw, Harvey Keitel, James Russo, Lou Reed, Michael J. Fox, Roseanne, Jim Jarmusch, Jared Harris, Mira Sorvino, Keith David, RuPaul, Tim Roth, Jennifer Beals, Antonio Banderas, Valeria Golino, David Proval, Quentin Tarantino, Paul Calderon, Ione Skye, Lili Taylor, Sammi Davis, Tamlyn Tomita, Alicia Witt, Marisa Tomei, Amanda DeCadenet, Marc Lawrence, Kathy Griffin, Salma Hayek, Bruce Willis, Theresa Randle, Isaiah Washington, Spike Lee, Jenifer Lewis, Debi Mazar, Peter Berg, Michael Imperioli, Ron Silver, Halle Berry, Kristen Wilson, Gretchen Mol, Mekhi Phifer, Jonathan Pryce, Jimmy Nail, Adriá Collado, Andrea Corr, Rupert Everett, Benjamin Bratt, Michael Vartan, Lynn Redgrave, Neil Patrick Harris, Illeana Douglas, Clive Owen, Adriano Giannini, Bruce Greenwood, Jeanne Tripplehorn, Elizabeth Banks, David Thornton, Michael Beattie, Pierce Brosnan, Toby Stephens, Rosamund Pike, Rick Yune, Judi Dench, John Cleese, Michael Madsen, Will Yun Lee, Eric McCormack, Debra Messing, Sean Hayes, Megan Mullally, Freddie Highmore, David Bowie, David Suchet, Jimmy Fallon, Emilio Estevez, Robert De Niro, Harvey Keitel, Rob Corddry, Erik Per Sullivan, Chazz Palminteri, Anthony Anderson, Jason Bateman,
En sus videoclips aparecen: Debi Mazar, John Leguizamo, Matthew Modine, Linda Fiorentino, Keith Carradine, Robert Wuhl, Sean Penn, Christopher Walken, Mary Stuart Masterson, Chris Penn, Danny Aiello, Benicio del Toro, Leon Robinson, Tony Ward, Helmut Berger, Naomi Campbell, Udo Kier, Isabella Rossellini, Sofia Coppola, Tomas Arana, Matt Dillon, James Rebhorn, Mark Margolis, Michael Kenneth Williams, Antonio Banderas, Jonathan Pryce, Anita Pallenberg, Goran Visnjic, Mike Myers, Verne Troyer, Michael York, Rupert Everett, Sacha Baron Cohen, Britney Spears, Sofia Boutella, Justin Timerlake, Timbaland, Pharrell Williams, Nicki Minaj, M.I.A, Beyoncé, Miley Cyrus, Diplo, Jon Kortajarena, Rita Ora, Katy Perry, Chris Rock, Kanye West, Maluma, Snoop Dogg, Tokischa
Ha cantado junto a los siguientes artistas: Britney Spears, Justin Timerlake, Timbaland, Pharrell Williams, Missy Elliott, Nicki Minaj, M.I.A., Ariana Grande, Maluma, Swae Lee, Dua Lipa, Tokischa
Como directora de cine ha dirigido a: Richard E. Grant, Stephen Graham, Abbie Cornish, James D´Arcy, Andrea Riseborough, Oscar Isaac, Richard Coyle, David Harbour, James Fox, Judy Parfitt, Geoffrey Palmer, Natalie Dormer, Annabelle Wallis
